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Recent advances in in-silico approaches for enzyme engineering

in Algorithms/Softwares/Tools by

Enzymes are natural biocatalysts and an attractive alternative to chemicals providing improved efficiency for biochemical reactions. They are widely utilized in industrial biotechnology and biocatalysis to introduce new functionalities and enhance the production of enzymes. In order to be proved beneficial for the industrial purposes, the enzymes need to be optimized by applying protein engineering. This article specifically reviews the recent advancements in the computational approaches for enzyme engineering and structural determination of the enzymes developed in recent years to improve the efficiency of enzymes, and the creation of novel functionalities to obtain
products with high added value for industrial applications.
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Alignment-free approaches for Sequence Analysis

in Algorithms/Sequence Analysis/Tools by

Multiple Sequence Alignment (MSA) is a fundamental aspect of Bioinformatics in order to identify the species, their functions, phylogeny, study the novel genes/ proteins, and so on. Multiple MSA tools are available with different specifications, which are based on the heuristic algorithm focusing on the speed rather than the accuracy. Continue reading “Alignment-free approaches for Sequence Analysis” »

New features to predict miRNA target sites in mRNAs

in Algorithms/Machine Learning by

In order to study gene regulation, it is necessary to identify the target sites of miRNA in mRNA. miRNAs have been the main point of research as its binding to mRNA degrades the target mRNA and also prevents the translation of target mRNAs [1-4]. The identification of miRNA target sites, target mRNAs and the potential functional roles of miRNA may be assigned. Continue reading “New features to predict miRNA target sites in mRNAs” »

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