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Intrinsically disordered proteins’ predictors and databases: An overview

Intrinsically unstructured proteins (IUPs) are the natively unfolded proteins which must be unfolded or disordered in order to perform their functions.  They are commonly referred as intrinsically disordered proteins (IDPs) and play significant roles in regulating and signaling biological networks [1]. IDPs are also involved in the assembly of signaling complexes and in the dynamic self-assembly of membrane-less nuclear and cytoplasmic organelles [1]. The disordered regions in a protein can be highly conserved among the species in respect of both the composition and the sequence [2]. Continue reading “Intrinsically disordered proteins’ predictors and databases: An overview” »

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Algorithms/Softwares

Basic Concept of Multiple Sequence Alignment

Multiple Sequence Alignment (MSA) is a very basic step in the phylogeny analysis of organisms. In MSA, all the sequences under study are aligned together pairwise on the basis of similar regions with in them.  The major goal of MSA pairwise alignment is to identify the alignment that maximizes the protein sequence similarity. Keep Reading

CADD

Computer and Drugs: What you need to know

Would you chance your life to a lowly piece of hardware called the computer? Would you let it fabricate and determine drugs for life threatening diseases like hepatitis, cancers and even AIDS? Well, actually your answer (or your opinion) doesn’t seem to matter. Because the world has moved over to the other side. Computers are… Keep Reading

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