Research on COVID-19 – BiR-nCov19 Drug Development Team

On the 31st of March 2020, Bioinformatics Review created a team of bioinformatics researchers from all over the world to find potential drug candidates for nCov-19. This group is a collaborative effort and works remotely from all over the world. This group has 150+ researchers from 21 Countries.

 

Updates

Read about our latest in silico vaccine candidate design against covid19.

Update: A multi-epitope in silico vaccine candidate designed for Covid-19

Read about our latest selection pressure study on spike glycoproteins of SARS-CoV.

Update: Selection analysis on spike glycoproteins of SARS-CoV

Read about our latest selection pressure study on spike glycoproteins of SARS-CoV-2.

Update: Selection analysis on spike glycoprotein of SARS-CoV-2

Read about our latest work on phylogenetics analysis of spike glycoproteins of SARS-CoV-2 and SARS-CoV.

Phylogenetics analysis of SARS-CoV-2 spike glycoproteins

 

Data

Find all the necessary files here.

Fig. 1 Phylogenetic tree of SARS-CoV-2 spike sequences with SARS-CoV spike sequences as an outgroup.

Fig. 2 MSA of all spike glycoprotein sequences of SARS-CoV-2 and SARS-CoV.

File 1 MSA of all spike glycoprotein sequences of SARS-CoV-2 and SARS-CoV showing conserved residues.

Fig. 3 Structure of Spike Glycoprotein (PDB ID: 6VXX) of SARS-CoV-2. The detected residues under positive selection are shown in red color.

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