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Drug Discovery

Prediction of biochemical reactions catalyzed by enzymes in humans

in Algorithms/Drug Discovery/Machine Learning by

There are many biological important enzymes which exist in the human body, one of them is Cytochrome P450 (CyP450) enzymes which are mostly considered in drug discovery due to their involvement in the majority (75%) of drug metabolism [1]. Therefore, various in-silico methods have been applied to predict the possible substrates of CyP 450 enzymes [2-4]. Recently, an in-silico model has been developed to predict the potential chemical reactions mediated by the enzymes present in humans including CyP450 enzymes [5]. Continue reading “Prediction of biochemical reactions catalyzed by enzymes in humans” »

A review on the effects of CMPF binding with Human Serum Albumin

in Drug Discovery by

The interaction amongst plasma proteins and drugs is an imperative pharmacological parameter which impacts their pharmaco-dynamic behaviors and influences the circulation and disposal of a drug, the structure, and physiological activity of transporter proteins [1, 2].The proteins bind to various drugs and the most essential being albumin. Continue reading “A review on the effects of CMPF binding with Human Serum Albumin” »

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