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Intrinsically disordered proteins’ predictors and databases: An overview

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Intrinsically unstructured proteins (IUPs) are the natively unfolded proteins which must be unfolded or disordered in order to perform their functions.  They are commonly referred as intrinsically disordered proteins (IDPs) and play significant roles in regulating and signaling biological networks [1]. IDPs are also involved in the assembly of signaling complexes and in the dynamic self-assembly of membrane-less nuclear and cytoplasmic organelles [1]. The disordered regions in a protein can be highly conserved among the species in respect of both the composition and the sequence [2]. Continue reading “Intrinsically disordered proteins’ predictors and databases: An overview” »

An introduction to the predictors of pathogenic point mutations

in Algorithms/Softwares/Tools by

Single nucleotide variation is a change in a single nucleotide in a sequence irrespective of the frequency of the variation. Single nucleotide variants (SNVs) play a very important role in causing several diseases such as the tumor, cancer, etc. Many efforts have been made to identify the SNVs which were initially based on identifying non-synonymous mutations in coding regions of the genomes. Continue reading “An introduction to the predictors of pathogenic point mutations” »

How to install AutoDock Vina on Ubuntu?

in Softwares/Tools by

AutoDock Vina is one of the most popular software in Bioinformatics, known for the molecular docking simulations. I have already explained the docking procedure in my previous article. In this small tutorial, we will learn how to install AutoDock Vina on Ubuntu. Its installation on Ubuntu may be a tedious process, especially for the beginners due to the unfamiliarity of the Linux commands. It is expected to work on any version of Ubuntu, but make sure whether your system supports the 32- bit or 64- bit version. If you face any problem, then feel free to ask. Continue reading “How to install AutoDock Vina on Ubuntu?” »

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