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Role of Information Theory, Chaos Theory, and Linear Algebra and Statistics in the development of alignment-free sequence analysis

in Algorithms/Sequence Analysis/Softwares by

Sequence alignment is a customary to not only find similar regions among a pair of sequences but also to study the structural, functional and evolutionary relationship between organisms. Many tools have been discovered to achieve¬†the goal of alignment of a pair of sequences, separately for nucleotide sequence and amino acid sequence, BLOSSUM & PAM [1] are a few to name. Continue reading “Role of Information Theory, Chaos Theory, and Linear Algebra and Statistics in the development of alignment-free sequence analysis” »

Recent advances in in-silico approaches for enzyme engineering

in Algorithms/Softwares/Tools by

Enzymes are natural biocatalysts and an attractive alternative to chemicals providing improved efficiency for biochemical reactions. They are widely utilized in industrial biotechnology and biocatalysis to introduce new functionalities and enhance the production of enzymes. In order to be proved beneficial for the industrial purposes, the enzymes need to be optimized by applying protein engineering. This article specifically reviews the recent advancements in the computational approaches for enzyme engineering and structural determination of the enzymes developed in recent years to improve the efficiency of enzymes, and the creation of novel functionalities to obtain
products with high added value for industrial applications.
Continue reading “Recent advances in in-silico approaches for enzyme engineering” »

Lipidomics: An overview

in Lipidomics/Softwares/Tools by

Lipids are the essential metabolites in human body performing different functions such as energy storage, endocrine actions, cell signaling, morphogenesis, and so on. Using lipidomics approach, it has become easier to study the lipids species in an organism. Continue reading “Lipidomics: An overview” »

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