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Evolution

Tutorial-I: Functional Divergence Analysis using DIVERGE 3.0 software

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diverge 3.0 tutorial

DIVERGE is a tool to detect functional divergence between member genes of a protein family based on (site-specific) shifted evolutionary rates after gene duplication or speciation [1]. Since this tool contains several steps and offers a lot to discover, therefore, we are going to split its tutorial into parts. In this article, we will perform some initial steps in this software and will explain their significance. Keep Reading

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Update: Selection analysis on spike glycoproteins of SARS-CoV

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In our last article, we mentioned the selection pressure analysis of SARS-CoV-2 spike glycoproteins. Now, we have analyzed spike glycoprotein sequences of SARS-CoV. No single purifying selection site was found in SARS-CoV spike glycoproteins as was revealed from our last analysis of SARS-CoV-2 spike glycoproteins. Keep Reading

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Update: Selection analysis on spike glycoprotein of SARS-CoV-2

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Figure 1. Protein Structure of Corona Virus - Ribbon View

We have recently conducted a selection pressure analysis on SARS-CoV-2 spike glycoprotein sequences. The analysis revealed not even a single site showing evidence of purifying selection but episodic diversifying selection on three sites. Out of these three sites, two sites are potentially relevant (Fig. 3). Keep Reading

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