Installing Autodock4 on MacOS.

Previously, we installed the Autodock suite [1] on Ubuntu. Visit this article for details. Now, let’s install it on MacOS.

Contents

Downloading Autodock 4.2.6 Installing Autodock 4.2.6 References

Autodock4 contains two main programs, namely, autogrid4 and autodock4. Autogrid4 calculates a set of grids that describe the target protein. Autodock4 performs the docking of the ligands to those grids [1]. We are installing Autodock 4.2.6 on MacOS.

Downloading Autodock 4.2.6

Download Autodock4 from here for Mac OS X in your desired folder.
You will see a new tar file, namely, ‘autodocksuite-4.2.6-MacOSX.tar’ in your folder.

Installing Autodock 4.2.6

To install Autodock4, double-click on the downloaded file.
It will create a new folder, namely, ‘MacOSX’.
Open this folder, you will find the two executable files: autogrid4 and autodock4.

References

Morris, G. M., Huey, R., Lindstrom, W., Sanner, M. F., Belew, R. K., Goodsell, D. S., & Olson, A. J. (2009). AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility. Journal of computational chemistry, 30(16), 2785-2791.