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Muniba Faiza - page 2

Muniba Faiza has 48 articles published.

SparkBLAST: Introduction

in Algorithms/Cloud Computing/Sequence Analysis by

The basic local alignment search tool (BLAST) [1,2] is known for its speed and results, which is also a primary step in sequence analysis. The ever increasing demand of processing huge amount of genomic data has led to the development of new scalable and highly efficient computational tools/algorithms. For example, MapReduce is the most widely accepted framework which supports design patterns representing general reusable solutions to some problems including biological assembly [3] and is highly efficient to handle large datasets running over hundreds to thousands of processing nodes [4]. But the implementation frameworks of MapReduce (such as Hadoop) limits its capability to process smaller data. Continue reading “SparkBLAST: Introduction” »

Systems pharmacology and drug development

in Algorithms/Drug Discovery/System Pharmacology/Systems Biology by

Systems pharmacology is an emerging area in the field of medicinal chemistry and pharmacology which utilizes systems network to understand drug action at the organ and organism level. It applies the computational and experimental systems biology approaches to pharmacology, which includes network analyzes at multiple biological organization levels facilitating the understanding of both therapeutic and adverse effects of the drugs. Nearly a decade ago, the term systems pharmacology was used to define the drug action in a specific organ system such as reproductive pharmacology [1], but to date, it has been expanded to different organ and organism levels [2]. Continue reading “Systems pharmacology and drug development” »

Recent advances in in-silico approaches for enzyme engineering

in Algorithms/Softwares/Tools by

Enzymes are natural biocatalysts and an attractive alternative to chemicals providing improved efficiency for biochemical reactions. They are widely utilized in industrial biotechnology and biocatalysis to introduce new functionalities and enhance the production of enzymes. In order to be proved beneficial for the industrial purposes, the enzymes need to be optimized by applying protein engineering. This article specifically reviews the recent advancements in the computational approaches for enzyme engineering and structural determination of the enzymes developed in recent years to improve the efficiency of enzymes, and the creation of novel functionalities to obtain
products with high added value for industrial applications.
Continue reading “Recent advances in in-silico approaches for enzyme engineering” »

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