Structure Prediction

Methodology for Homology Modeling of a Simple Protein


Previously, we have explained the initial methods involved in the structure prediction of a protein. In that article, we discussed the three basic methods involved in protein structure prediction: Homology modeling, ab-initio, and threading. In this article, we will explain the methodology involved in performing the homology modeling of a simple protein. Keep Reading

Homology Modeling of α-Glucosidase Enzyme: 3D Structure Prediction


The word “Homology modeling”, means comparative modeling or sometimes it is known as Template-Based Modeling (TBM), which refers to develop a three dimensional model of a protein structure by extracting the keen information’s from already experimentally known structure of a homologous protein (the template).  The 3D Protein structural information provides great assistance to study the function of different proteins, ligands interactions, dynamics, and Protein-Protein Interactions (PPI). Keep Reading

ab-initio prediction of protein structure: An introduction


We have heard a lot about the ab-initio term in Bioinformatics, which could be difficult to understand for newbies in the field of bioinformatics. Today, we will discuss in detail what ab-initio is and what are the applicable methods for it. Keep Reading

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