Rosetta is a bioinformatics software for modeling and protein structure analysis [1]. In this article, we are going to install this software on Ubuntu.

Preparing system

Open a terminal by pressing Ctrl+Alt+T. Update and upgrade your system using the following commands:

$ sudo apt-get update

$ sudo apt-get upgrade

Downloading Rosetta

To download Rosetta, you need to obtain a license that is free for academic users. Request a license from here.

After obtaining the license, download the software (tar file) in a directory, let’s say Downloads.

Installing Prerequisites

To install Rosetta on your system, you need to install another software called SCons. Paste the following command.

$ sudo apt-get install -y scons

Installing Rosetta

Change to the directory where you have downloaded the software.

$ cd Downloads/

Extract the downloaded file using the following command.

$ tar xvzf rosetta_src_3.12_bundle.tgz

It will create a new directory, namely, ‘rosetta_src_2020.08.61146_bundle‘. Now, move inside the new directory and install using the following commands.

$ cd rosetta_src_2020.08.61146_bundle/main/source/

$ ./scons.py -j 4 bin

It will take a few minutes to finish installing. After that, you are ready to use Rosetta onUbuntu.

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References

1. https://www.rosettacommons.org/software