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Systems Biology

Systems pharmacology and drug development

in Algorithms/Drug Discovery/System Pharmacology/Systems Biology by

Systems pharmacology is an emerging area in the field of medicinal chemistry and pharmacology which utilizes systems network to understand drug action at the organ and organism level. It applies the computational and experimental systems biology approaches to pharmacology, which includes network analyzes at multiple biological organization levels facilitating the understanding of both therapeutic and adverse effects of the drugs. Nearly a decade ago, the term systems pharmacology was used to define the drug action in a specific organ system such as reproductive pharmacology [1], but to date, it has been expanded to different organ and organism levels [2]. Continue reading “Systems pharmacology and drug development” »

MOTIF: Functional Unit of An Interaction Network

in Systems Biology by

In a network, integration of elements and interacting components enables identification of conserved modules and
motifs. The topological analysis, however, reveals much about the nature and functions of a network and provides sufficient statistics for any further study. Continue reading “MOTIF: Functional Unit of An Interaction Network” »

Network Biology: Get Together of Macromolecules

in Systems Biology by

A network is a group of two more than two interacting components. The complex biological systems can be represented as computable networks that provide a unique way of analyzing the complex underlying mechanisms. Continue reading “Network Biology: Get Together of Macromolecules” »

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