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Structural Identification of Macromolecules in solution with DARA web server

in Algorithms/Bioinformatics News/Softwares by

To study macromolecules in homogenous solution, a technique known as SAXS ( Small Angle X-ray Scattering) is used where the obtained scattering patterns are used to design the structure of macromolecules that are proteins, mucleic acids and protein:nucleic acid complexes. Continue reading “Structural Identification of Macromolecules in solution with DARA web server” »

MUSCLE: Tool for Multiple Sequence Alignment

in Algorithms/Softwares/Tools by

In my last article I discussed about the Multiple Sequence Alignment and its creation. Now in this article, I am going to explain the workflow of one of the MSA tool, i.e., MUSCLE. MUSCLE is a software which is used to create MSA of the sequences of interest.  Continue reading “MUSCLE: Tool for Multiple Sequence Alignment” »

Basic Concept of Multiple Sequence Alignment

in Algorithms/Softwares by

Multiple Sequence Alignment (MSA) is a very basic step in the phylogeny analysis of organisms. In MSA, all the sequences under study are aligned together pairwise on the basis of similar regions with in them.  The major goal of MSA pairwise alignment is to identify the alignment that maximizes the protein sequence similarity. Continue reading “Basic Concept of Multiple Sequence Alignment” »

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