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McPAS-TCR: A database of TCR sequences associated with pathology and antigens

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T-cells, also known as T-lymphocytes, play important role in the cell-mediated immune system. T-cells consist of a T-cell receptor (TCR) at their surface which recognizes the foreign and self- origin antigens. These TCRs composed of two chains, namely, TCRα and TCRβ chains which are produced by a random process of DNA rearrangement [1,2]. These TCR repertoires are highly diverse ensuring an effective immune system which cannot be even captured in a blood sample [3]. Continue reading “McPAS-TCR: A database of TCR sequences associated with pathology and antigens” »

miRBase: Explained

in Algorithms/Databases/Softwares by

Micro RNAs (miRNAs) are the short endogenous RNAs (~22 nucleotides) and originate from the non-coding RNAs [1], produced in single-celled eukaryotes, viruses, plants, and animals [2]. miRNAs are capable of controlling homeostasis [2] and play significant roles in various biological processes such as degradation of mRNA and post-translational inhibition through complementary base pairing [3].  Continue reading “miRBase: Explained” »

Machine learning in prediction of ageing-related genes/proteins

in Algorithms/Databases/Machine Learning by

Ageing has a great impact on human health, when people’s age advance towards 80 years, approximately half of the proteins in the body get damaged through oxidation. The chemical degradations occurring in our body produce energy by the consumed food via oxidation in the presence of oxygen. Continue reading “Machine learning in prediction of ageing-related genes/proteins” »

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