Protein-protein interactions (PPIs) have become necessary in order to study many biological processes. In order to study the PPIs, the binding affinity among the proteins is...
miRNAs are the small endogenous non-coding RNAs having a length less than or ~22 nucleotides. miRNAs are expressed from long transcripts formed in animals, viruses, single-celled eukaryotes...
In this rising era of personalized medicine, drug discovery, data refining, chemical compound databases, drug information, identification of symptoms by various levels of biomarkers, bioinformatics have...
Network visualization has become a strong need for studying the molecular interactions whether they are the protein or gene interactions. Network information is utilized in many...
Secondary structure formation and conformational changes play a key role in understanding molecular evolution and its functional aspects. Among DNA, RNA, and Protein, secondary structure analyses...
What is predictive metagenomics profiling? Recently, predictive metagenomics profiling (PMP) has been added to the microbial ecologist’s arsenal of strategies for probing microbial communities.
This is the second article under the popular series “Do you HYPHY…”, recently published online in BiR. In this issue, I would like to take the...
The identification and assignment of functions of unknown macro molecules has been observed to be faster and reliable than the sequence-based methods. This may be due...
As I have discussed in my earlier articles about the multiple sequence alignment (MSA) tools (MUSCLE & T-COFFEE). Now in this article, we will discuss different...
T-Coffee is a multiple sequence alignment tool which stands for Tree-based Consistency Objective Function for alignment Evaluation. It is a simultaneous alignment which combines the best...
HyPhy, acronym for Hypothesis Testing Using Phylogenies (www.hyphy.org) was written & designed by Kosakovsky Pond and workers to provide likelihood-based analyses on molecular evolutionary data sets...
Perl one-liners are extremely short Perl scripts written in the form of a string of commands that fits onto one line. That would amount to a...
The Microbial Pan Genome is the union of genes shared by genomes of interest. This term was first used by Medini in 2005.
As the needs say the importance of sequencing of genomes, it is equally important to visualize them. There exists some tools to visualize the genomes,but they...
In bioinformatics, GROMACS is one of the most popular Molecular Dynamics simulation software with loads of features built-in. Installing GROMACS Version 5.x.x+ can be a tedious...
After a lot of work in the field of bioinformatics, many of the living organisms’ genome has been sequenced and a lot of information has been...
CRISPR/Cas9 system is a bacterial defence mechanism against bacteriophage infection. When a viral dna(Bacteriophage, in this case) integrates into the bacterial genome, it produces RNA which...
In my last article I discussed about the Multiple Sequence Alignment and its creation. Now in this article, I am going to explain the workflow of...
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